Methylsulfonylmethane (MSM) is a chemical found in green plants, animals, and humans. It can likewise be made in a laboratory. MSM has become popular because of the book the miracle of MSM: the natural service for discomfort. However there is little released scientific research to support its use. Contrary to some literature that promotes MSM, there is no suggested dietary allowance (rda) for MSM or sulfur, which remains in MSM. Sulfur deficiency has not been described in the medical literature.

Individuals take MSM by mouth and use it to the skin for persistent pain, osteoarthritis, joint swelling, rheumatoid arthritis, osteoporosis, inflammation around the joints (bursitis), tendinitis, swelling around the tendons (tenosynovitis), musculoskeletal pain, muscle cramps, solidified skin condition called scleroderma, scar tissue, stretch marks, hair loss, wrinkles, security versus sun/wind burn, eye swelling, oral health, gum disease, wounds, cuts, and abrasions/accelerated injury healing.

People also take MSM by mouth for relief of allergies, persistent constipation, “sour stomach”, ulcers, a bowel disease called diverticulosis, premenstrual syndrome (pms), state of mind elevation, weight problems, poor blood circulation, hypertension, and high cholesterol. It is likewise taken by mouth for type 2 diabetes, liver problems, alzheimer’s illness, to control snoring, lung disorders including emphysema and pneumonia, chronic fatigue syndrome, autoimmune disorders (systemic lupus erythematous), hiv infection and aids, and cancer (breast cancer and colon cancer).

MSM is also taken by mouth for eye swelling, mucous membrane inflammation, temporomandibular joint (tmj) problems, leg cramps, migraine, headaches, hangover, parasitic infections of the digestive and urogenital systems including trichomonas vaginalis and giardia, yeast infection, insect bites, radiation poisoning, and to enhance the body immune system.

How does it work?

MSM may provide sulfur to make other chemicals in the body. [1]


Most research study on MSM includes animal studies. MSM has actually been suggested for usage as a food supplement and is offered in the united states as a dietary supplement under the dietary supplement health and education act.


MSM is a typical oxidation product of dimethyl sulfoxide (dmso). Unlike dmso, MSM is odor totally free and is a dietary factor. MSM has been referred to as “crystalline dmso.” bertken 1983 MSM supplies a dietary source of sulfur for methionine.richmond 1986 MSM’s medicinal residential or commercial properties are theorized to be similar to dmso, without the odor and skin irritation issues.


The sulfur content of MSM can be utilized by the body to preserve regular connective tissues. MSM has actually also exhibited possible anti-inflammatory, antiatherosclerotic, and chemopreventative activities along with totally free extreme scavenging. MSM has been reported to minimize allergic reactions, arthritis, gi upset, musculoskeletal pain, and to enhance the immune system. It likewise has antimicrobial results versus organisms such as giardia lamblia, trichomonas vaginalis, and some fungis. The recommended system is that MSM might bind to surface receptor websites, blocking the interaction of parasite and host. [2]

Dietary sources of MSM

It’s not hard to get MSM by means of your diet plan. MSM is naturally found in:.

  1. Fresh vegetables and fruits
  2. Milk
  3. Fish
  4. Grains

This doesn’t necessarily indicate you’re getting a lot through your diet plan, though. As foods are processed, MSM is ruined. You may have the ability to increase the quantity you get in food by focusing on fresh whole foods.

Natural vs. Created MSM

While MSM exists in nature, the kind that’s marketed as a supplement is a chemical compound originated from dmso (dimethyl sulfoxide).

Dmso is offered in a commercial grade and a medical-grade. Dmso was promoted as a wonder treatment for arthritis in the 1960s but ended up being controversial because of possible problems and unpleasant side effects. As dmso faded from usage as an arthritis treatment, MSM acquired momentum.

Types of MSM

MSM is mostly sold non-prescription as an oral solution (solution, tablets, or capsules). It is often combined with other dietary supplements, such as:.

Some multi-ingredient joint solutions consist of lots of other supplements, too.

MSM is also available as a topical cream.

MSM research study

MSM not only reduces swelling, but it likewise safeguards your cartilage from deterioration, such as that seen in osteoarthritis, by reducing interleukin 1-beta (il-1b) and tumor necrosis factor-alpha (tnf-a), according to an evaluation of literature published in 2017.

The result of lowered inflammation and cartilage conservation is an enhanced range of motion and physical function.

MSM can likewise minimize exercise-related muscle damage, particularly when taken before laborious resistance or endurance exercises, the review states. This is believed to be due to its antioxidant effects. [3]

8 science-backed advantages of MSM supplements

Methylsulfonylmethane, more typically called MSM, is a popular dietary supplement utilized to deal with a large selection of signs and conditions.

It’s a sulfur-containing substance found naturally in plants, animals and human beings. It can likewise be produced in a laboratory to create dietary supplements in powder or capsule kind.

MSM is extensively utilized in the alternative medicine field and by individuals trying to find a natural method to relieve joint pain, reduce inflammation and boost resistance.

In addition, research supports its usage in treating a variety of conditions from arthritis to rosacea.

Here are 8 science-backed health benefits of MSM.

Can decrease joint pain, which might improve your quality of life

Among the most popular uses of MSM is to decrease joint or muscle discomfort.

It has actually been revealed to benefit those with joint degeneration, a common reason for discomfort in the knees, back, hands and hips.

Joint degeneration can negatively impact your lifestyle by restricting your movement and mobility.

Research studies have revealed that MSM substantially lowers swelling in your body. It also hinders the breakdown of cartilage, a flexible tissue that safeguards the ends of your bones in joints.

A research study in 100 individuals over the age of 50 discovered that treatment with a supplement including 1,200 mg of MSM for 12 weeks reduced discomfort, stiffness and swelling in the joints, compared to a placebo.

The group receiving the supplement also reported improved total quality of life and less trouble walking and getting out of bed.

Another research study in 32 people with lower back pain found that taking a glucosamine supplement consisting of MSM considerably decreased lumbar tightness and discomfort upon movement, plus greatly increased quality of life.


Studies have revealed that MSM works in minimizing joint discomfort, tightness and swelling. In doing so, it can enhance your quality of life.

Has anti-inflammatory impacts, such as increasing glutathione levels

The anti-inflammatory properties of MSM are well documented by clinical research study.

It’s believed that MSM hinders nf-kb, a protein complex involved in inflammatory responses in your body.

It likewise decreases the production of cytokines such as growth necrosis element alpha (tnf-ɑ) and interleukin 6 (il-6), which are signaling proteins connected to systemic inflammation.

Furthermore, MSM can increase levels of glutathione, a potent anti-oxidant produced by your body.

For example, supplementing with MSM significantly lowered inflammation in mice with stomach ulcers by preventing the release of inflammatory cytokines consisting of tnf-ɑ and il-6, along with increasing glutathione levels.

Another study in 40 physically active guys showed that taking 3 grams of MSM before extensive exercise decreased the release of inflammatory cytokines and avoided the over-stress of immune cells, compared to a placebo.


MSM may minimize the release of particles associated with swelling, such as tnf-ɑ and il-6, as well as increase levels of the powerful antioxidant glutathione.

Can speed healing after workout by decreasing muscle damage and stress

During extensive exercise, muscle damage happens and oxidative stress increases.

This triggers athletes to experience muscle discomfort and discomfort, which can hinder athletic performance and training.

MSM can naturally speed muscle healing after intense exercise by decreasing swelling and oxidative tension.

A study in 18 guys revealed that taking 50 mg of MSM powder per kg of body weight for 10 days significantly decreased exercise-induced muscle damage and increased antioxidant activity following an 8.7 mile (14 km) run.

It may also be helpful for decreasing discomfort after extended workout.

In one study, 22 healthy ladies received 3 grams of MSM or a placebo daily for 3 weeks leading up to a half marathon. The MSM group reported less muscle soreness and joint discomfort than the placebo group.

Another research study discovered that athletic males taking 3 grams of MSM daily for 2 weeks had lower levels of il-6 and less muscle pain after extreme resistance workout.


MSM might help in reducing discomfort, muscle damage and oxidative tension after intense exercise, assisting you recuperate quicker.

Assists minimize arthritis signs by minimizing pain and stiffness

Arthritis is a common inflammatory condition that triggers discomfort, tightness and a minimized series of motion in your joints.

Since MSM has effective anti-inflammatory homes, it’s often utilized as a natural alternative to medications to improve arthritis-related signs.

A study in 49 individuals with knee osteoarthritis discovered that taking 3.4 grams of MSM daily for 12 weeks decreased discomfort and stiffness and improved physical function, compared to a placebo.

In addition, it can enhance the efficiency of other typical supplements used to treat arthritis such as glucosamine sulfate, chondroitin sulfate and boswellic acid.

One research study discovered that integrating MSM with glucosamine and chondroitin was more efficient at reducing pain and tightness in individuals with knee osteoarthritis than glucosamine and chondroitin alone.

Another research study revealed that an everyday supplement containing 5 grams of MSM and 7 grams of boswellic acid was more efficient than glucosamine at minimizing discomfort and improving function in people with knee osteoarthritis.

What’s more, individuals who received the MSM and boswellic acid supplement were less depending on anti-inflammatory medications than the glucosamine group.


MSM supplements have actually been shown to help in reducing pain and tightness in individuals with arthritis. They might likewise help improve physical function.

May help alleviate allergic reaction symptoms by decreasing inflammation

Allergic rhinitis is an allergy that triggers symptoms such as watery eyes, sneezing, itching, runny nose and nasal blockage.

Common triggers of hay fever consist of animal dander, pollen and molds.

After direct exposure to an irritant, many inflammatory substances such as prostaglandins and cytokines are launched, which results in unpleasant symptoms.

Studies have actually shown that MSM may work in lowering signs of hay fever.

It might reduce allergic reactions by reducing swelling and preventing the release of cytokines and prostaglandins.

A study in 50 individuals with allergic rhinitis found that a dose of 2,600 mg of MSM per day over one month reduced signs consisting of itching, blockage, shortness of breath, sneezing and coughing.

Furthermore, individuals experienced a considerable increase in energy by day 14.


MSM may help in reducing allergy-related signs– including coughing, shortness of breath, blockage, sneezing and fatigue– by lowering inflammation.

Can improve resistance and assist you stay healthy

Your immune system is a specific network of tissues, cells and organs that protects your body against disease and disease.

It can be compromised by things like tension, illness, a bad diet, inadequate sleep or absence of activity.

Sulfur compounds such as MSM play crucial functions in the health of your immune system.

For instance, MSM may be effective in reducing oxidative stress and inflammation that can damage immunity. Considering that it works in minimizing levels of inflammatory substances like il-6 and tnf-ɑ, MSM may lower tension on your body immune system.

Additionally, it plays a part in the development of glutathione, your body’s master antioxidant. It may also assist increase levels of this essential compound.

Having appropriate levels of glutathione is crucial for the overall health and function of your body immune system.

A test-tube research study showed that MSM effectively brought back glutathione levels and decreased inflammatory markers in mouse cells that had been damaged with hiv proteins.


MSM might help increase your immune system by lowering inflammation and increasing glutathione levels.

Could enhance skin health by enhancing keratin

Keratin is a protein that serves as the main structural component in your hair, skin and nails.

It consists of high levels of the sulfur-containing amino acid cysteine. That’s why scorched hair produces a characteristic sulfurous odor.

MSM might be helpful for skin health by serving as a sulfur donor to keratin. This, in turn, can assist enhance this crucial protein.

MSM also helps in reducing inflammation, which can damage skin cells and cause signs of premature aging like wrinkles.

It may even lower signs of problematic skin conditions such as rosacea, which can cause inflammation, irritation and inflammation of the skin.

One research study showed that, when applied to the skin, MSM substantially enhanced inflammation, itching, inflammation, hydration and skin color in individuals with rosacea.


MSM may enhance skin health by enhancing keratin and minimizing swelling. It might even help reduce signs of specific skin problem, too.

May have cancer-fighting properties

One of the latest areas of research involving MSM is studying its efficiency in fighting cancer cells. Although the research study is limited, the results have actually been assuring so far.

Numerous test-tube research studies have actually shown that MSM inhibits the growth of stomach, esophageal, liver, colon, skin and bladder cancer cells.

It seems to do this by damaging cancer cell dna and promoting cancer cell death.

MSM also appears to prevent the spread of cancer cells, also known as metastasis.

A research study in mice with liver cancer revealed that those injected with MSM had fewer tumors, smaller sized tumor size and less liver damage than those who did not receive the treatment.

Another mouse study showed that MSM inhibited the development of human breast cancer cells.

Although these results are motivating, more research is needed to identify the security and effectiveness of using MSM in cancer treatment.


Research has actually shown that MSM shows cancer-fighting homes in test-tube and animal studies, however more research is required. [4]

What are the side effects of MSM supplements?

Common side effects associated with MSM consist of:.

  • Diarrhea
  • Stomach pain
  • Queasiness

Opposite effects consist of:.

  • Swelling
  • Tiredness
  • Difficulty concentrating
  • Sleeping disorders
  • Headache [5]

The long-term security of methylsulfonylmethane (MSM) is not popular, however MSM is probably safe to consider approximately 6 months. [6]

How to avoid negative effects when taking MSM

1. Start slowly

Start with any new supplement it is generally an excellent idea to start with a small dosage and increase your dose gradually so that you can expect negative effects and assessment how the supplement is working for you. You can even begin with 1/2 or 1/4 or the manufacturer’s recommended dosage.

2. Inspect labels

Look for included ingredients in your supplement. In some cases the active ingredients added in the processing of supplements is the true perpetrator in negative effects.

3. Use a quality brand name

Use a brand that was advised to you by somebody you know, or your natural health professional.

4. Take MSM early in the day

Do not take MSM late in the day or at bedtime to avoid the side effect of sleeping disorders.

5. Take MSM with food

When you first begin taking MSM, it is recommended to take it with food. It is more common to have negative effects from brand-new supplements when you take them on an empty stomach.

MSM: is it for everyone?

Some who have reactions to sulfa drugs likewise have problem with MSM, so if you have reactions to sulfa drugs, you MSM may not be the best solution for you.

People with mood conditions seem to be more likely to have serious mental negative effects like anxiety and anxiety.

If you have moderate to serious nutritional deficiencies, MSM might exacerbate that issue. MSM can diminish molybdenum, an essential trace element.

People who take prescription or nonprescription medications on a regular basis might discover that MSM affects the method their medications work.

Those whose bodies are severely toxic or ill are at greater threat for detox responses and adverse effects. It might not be that MSM is the issue, however if it eliminates undesirable metals or parasites from your body when you take it, your body might feel rather ill during the detox procedure.

If MSM triggers adverse effects for you, or appears incompatible with your situation, do not despair. There are many wonderful natural solutions to think about in lieu of MSM. [7]

How should I use this medicine?

Take by mouth with a glass of water. Follow the instructions on the plan labeling or ask your healthcare expert. Do not take this supplement more often than directed.

Speak with your pediatrician concerning using this supplement in kids. Unique care may be required.

Overdosage: if you think you have actually taken excessive of this medicine contact a toxin nerve center or emergency room at the same time.

What if I miss a dosage?

If you miss a dose, take it as quickly as you can. If it is almost time for your next dosage, take only that dosage. Do not take double or extra doses.

What may communicate with this medicine?

Contact your physician or health care professional if you are taking any of the following medications:.

  • Diflunisal
  • Medicines that treat or avoid embolism like aspirin, dalteparin, enoxaparin, ticlopidine, warfarin
  • Nsaids, medicines for discomfort and inflammation, like ibuprofen or naproxen
  • Other natural supplements

This list may not describe all possible interactions. Offer your health care supplier a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you utilize. Also tell them if you smoke, consume alcohol, or use controlled substances. Some products may engage with your medication.

What should I watch for while using this medicine?

See your medical professional if your signs do not get better or if they become worse.

If you are set up for any medical or dental procedure, tell your healthcare provider that you are taking this supplement. You might require to stop taking this supplement before the treatment.

Herbal or dietary supplements are not regulated like medicines. Rigid quality assurance standards are not required for dietary supplements. The pureness and strength of these items can differ. The security and effect of this dietary supplement for a specific illness or health problem is not popular. This item is not meant to identify, deal with, treat or avoid any illness.

The fda recommends the following to help customers secure themselves:

  • Constantly check out item labels and follow directions.
  • Natural does not imply an item is safe for people to take.
  • Search for products that consist of usp after the active ingredient name. This suggests that the maker followed the standards of the us pharmacopoeia.
  • Supplements made or sold by a nationally known food or drug company are more likely to be made under tight controls. You can write to the business for more details about how the product was made. [8]

Keep in mind

MSM has usually been utilized by grownups in doses of 1-6 grams by mouth daily for approximately 16 weeks. [9]

Unique precautions and cautions

Pregnancy and breast-feeding: there isn’t enough trustworthy details to understand if MSM is safe to utilize when pregnant or breast feeding. Remain on the safe side and prevent usage.

Varicose veins and other circulatory problems (persistent venous deficiency): applying a lotion that contains MSM to the lower limbs can increase swelling and discomfort in people with varicose veins and other circulatory issues. [10]


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