Lithium is a kind of metal that is consumed in the diet, generally in grains and vegetables. Numerous forms are used in supplements in small dosages.

Lithium gets its name from “lithos,” the Greek word for stone, due to the fact that it is present in trace amounts in essentially all rocks. It might help mental illness by increasing the activity of chemical messengers in the brain. Lithium may likewise be needed for other functions, like the development of blood cells.

People use lithium supplements for alcohol use disorder, Alzheimer illness, depression, and lots of other conditions, but there is no good clinical proof to support any of these usages.

Lithium carbonate and lithium citrate are approved by the U.S. FDA as prescription drugs for bipolar disorder. These and other lithium drugs aren’t covered in this topic. Lithium supplements consist of much lower dosages of lithium than drugs. [2]


Petalite (LiAlSi4O10) was discovered in 1800 by the Brazilian chemist and statesman José Bonifácio de Andrada e Silva in a mine on the island of Utö, Sweden. Nevertheless, it was not up until 1817 that Johan August Arfwedson, then operating in the laboratory of the chemist Jöns Jakob Berzelius, discovered the presence of a new aspect while analyzing petalite ore. This component formed compounds comparable to those of sodium and potassium, though its carbonate and hydroxide were less soluble in water and less alkaline. Berzelius provided the alkaline product the name “lithion/lithina”, from the Greek word λιθoς (transliterated as lithos, meaning “stone”), to reflect its discovery in a solid mineral, as opposed to potassium, which had been discovered in plant ashes, and salt, which was known partly for its high abundance in animal blood. He named the metal inside the product “lithium”.

Arfwedson later showed that this very same aspect existed in the minerals spodumene and lepidolite. In 1818, Christian Gmelin was the first to observe that lithium salts provide a bright red color to flame. However, both Arfwedson and Gmelin attempted and failed to isolate the pure element from its salts. It was not isolated until 1821, when William Thomas Brande got it by electrolysis of lithium oxide, a process that had actually formerly been used by the chemist Sir Humphry Davy to isolate the alkali metals potassium and salt. Brande also explained some pure salts of lithium, such as the chloride, and, approximating that lithia (lithium oxide) consisted of about 55% metal, approximated the atomic weight of lithium to be around 9.8 g/mol (modern worth ~ 6.94 g/mol). In 1855, larger amounts of lithium were produced through the electrolysis of lithium chloride by Robert Bunsen and Augustus Matthiessen. The discovery of this treatment.

caused industrial production of lithium in 1923 by the German company Metallgesellschaft AG, which carried out an electrolysis of a liquid mixture of lithium chloride and potassium chloride.

Australian psychiatrist John Cade is credited with reintroducing and promoting making use of lithium to deal with mania in 1949. Quickly after, throughout the mid20th century, lithium’s mood supporting applicability for mania and depression took off in Europe and the United States.

The production and use of lithium went through a number of extreme modifications in history. The first major application of lithium remained in high-temperature lithium greases for aircraft engines and comparable applications in The second world war and shortly after. This use was supported by the truth that lithium-based soaps have a higher melting point than other alkali soaps, and are less corrosive than calcium based soaps. The small need for lithium soaps and lubricating greases was supported by numerous small mining operations, mainly in the United States.

The need for lithium increased considerably during the Cold War with the production of nuclear fusion weapons. Both lithium-6 and lithium-7 produce tritium when irradiated by neutrons, and are thus useful for the production of tritium by itself, as well as a type of solid fusion fuel used inside hydrogen bombs in the form of lithium deuteride. The US ended up being the prime producer of lithium in between the late 1950s and the mid1980s. At the end, the stockpile of lithium was approximately 42,000 tonnes of lithium hydroxide. The stockpiled lithium was depleted in lithium-6 by 75%, which was enough to affect the measured atomic weight of lithium in lots of standardized chemicals, and even the atomic weight of lithium in some “natural sources” of lithium ion which had been “infected” by lithium salts released from isotope separation facilities, which had actually discovered its method into ground water.

Lithium is utilized to decrease the melting temperature level of glass and to improve the melting behavior of aluminium oxide in the Hall-Héroult procedure. These two usages controlled the market until the middle of the 1990s. After completion of the nuclear arms race, the demand for lithium reduced and the sale of department of energy stockpiles on the open market further lowered rates. In the mid1990s, a number of companies began to isolate lithium from salt water which proved to be a more economical alternative than underground or open-pit mining. Most of the mines closed or moved their focus to other products since just the ore from zoned pegmatites could be mined for a competitive price. For example, the United States mines near Kings Mountain, North Carolina closed prior to the beginning of the 21st century.

The advancement of lithium ion batteries increased the demand for lithium and became the dominant usage in 2007. With the surge of lithium demand in batteries in the 2000s, new business have expanded salt water seclusion efforts to satisfy the rising need.

It has actually been argued that lithium will be among the primary objects of geopolitical competitors in a world working on renewable resource and based on batteries, however this viewpoint has actually likewise been criticized for ignoring the power of economic incentives for expanded production. [3]

Event and production

Discovered in 1817 by Swedish chemist Johan August Arfwedson in the mineral petalite, lithium is likewise discovered in salt water deposits and as salts in mineral springs; its concentration in seawater is 0.1 part per million (ppm). Lithium is also found in pegmatite ores, such as spodumene (LiAlSi2O6) and lepidolite (of varying structure), or in amblygonite (LiAlFPO4) ores, with Li2O contents ranging in between 4 and 8.5 percent. It makes up about 0.002 percent of Earth’s crust.

The table of elements is comprised of 118 components. How well do you understand their signs? In this test you’ll be shown all 118 chemical signs, and you’ll need to choose the name of the chemical component that every one represents.

Up until the 1990s the lithium chemical and metal market was controlled by American production from mineral deposits, however by the turn of the 21st century most production was derived from non-U.S. sources; Australia, Chile, and Portugal were the world’s largest suppliers. (Bolivia has half the world’s lithium deposits but is not a major manufacturer of lithium.) The significant business kind is lithium carbonate, Li2CO3, produced from ores or salt water by a variety of different processes. Addition of hydrochloric acid (HCl) produces lithium chloride, which is the compound used to produce lithium metal by electrolysis. Lithium metal is produced by electrolysis of a merged mix of lithium and potassium chlorides. The lower melting point of the mix (400– 420 ° C, or 750– 790 ° F) compared to that of pure lithium chloride (610 ° C, or 1,130 ° F) permits lower-temperature operation of the electrolysis. Because the voltage at which decay of lithium chloride takes place is lower than that of potassium chloride, lithium is transferred at a purity level greater than 97 percent. Graphite anodes are used in the electrolytic production of lithium, while the cathodes are made from steel. The pure lithium formed at the cathode coalesces at the surface area of the electrolyte to form a molten pool, which is secured from reaction with air by a thin movie of the electrolyte. The lithium is ladled from the cell and cast by pouring it into a mold at a temperature level just somewhat above the melting point, leaving the solidified electrolyte behind. The solidified lithium is then re melted, and products insoluble in the melt either float to the surface area or sink to the bottom of the melt pot. The re melting step lowers the potassium material to less than 100 parts per million. Lithium metal, which can be drawn into wire and rolled into sheets, is softer than lead however harder than the other alkali metals and has the body-centred cubic crystal structure.

Lots of lithium alloys are produced directly by the electrolysis of molten salts, including lithium chloride in the presence of a second chloride, or by the use of cathode materials that engage with the transferred lithium, introducing other aspects into the melt. [4]

Residence of lithium substances

The residential or commercial properties or habits of lithium and its compounds vary significantly from the alkali metals family and resemble magnesium due to the diagonal relationship in the table of elements. Numerous basic salts of metal are generally hydrated and anhydrous salts are hygroscopic in nature (LiCl, LiBr, LiI, and so on). The structure of LiClO4, 3H2O, and Mg( ClO4) 2, 6H2O are similar in nature, both consist of octahedral groups. The electrode capacity for the redox reaction of lithium has the most affordable value due to the greatest ionization energy and small size of the atom. [5]

Lithium sources

Lithium does not take place complimentary in nature. It is found in small amounts in almost all igneous rocks and in the waters of mineral springs. The minerals which contain lithium consist of lepidolite, petalite, amblygonite, and spodumene. Lithium metal is produced electrolytically from the merged chloride. [6]

Mechanism of action

The precise system of action of Li+ as a mood-stabilizing agent is presently unidentified. It is possible that Li+ produces its results by interacting with the transportation of monovalent or divalent cations in neurons. An increasing number of researchers have pertained to the conclusion that the excitatory neurotransmitter glutamate is the crucial factor in comprehending how lithium works. Lithium has been revealed to change the inward and outward currents of glutamate receptors (particularly GluR3), without a shift in reversal potential. Lithium has been discovered to apply a dual impact on glutamate receptors, acting to keep the amount of glutamate active between cells at a steady, healthy level, neither excessive nor insufficient. It is postulated that excessive glutamate in the space in between neurons triggers mania, and insufficient, depression. Another mechanism by which lithium may assist to control mood consist of the non-competitive inhibition of an enzyme called inositol mono phosphatase. At the same time lithium’s action might be enhanced through the deactivation of the GSK-3B enzyme. The guideline of GSK-3B by lithium may impact the circadian clock. GSK-3 is understood for phosphorylating and hence inactivating glycogen synthase. GSK-3B has actually likewise been linked in the control of cellular response to damaged DNA. GSK-3 normally phosphorylates beta catenin, which results in beta catenin degratation. When GSK-3 is prevented, beta catenin increases and transgenic mice with overexpression of beta catenin reveal similar behaviour to mice treated with lithium. These outcomes recommend that increase of beta catenin might be a possible path for the healing action of lithium. [7]

Lithium uses

Lithium is the first chemical component in the Alkali Metals Group and has the sign Li with atomic number 3. It is a soft, silver-white metal coming from the alkali metal group of chemical aspects. Lithium is the lightest of all metals, has a density around half that of water, and is always found as a compound with other minerals due to its’ high levels of chemical activity when by itself.

Uses of lithium

Lithium and its substances have many commercial, technological and medical applications, consisting of:.

  1. Industrial applications– heat-resistant glass/ceramics, airplane building and construction
  2. Technological applications– lithium batteries (discovered in laptop computers, cell phones, and most recently, in electrical cars)
  3. Medical applications– state of mind stabilizers (treatment for bipolar disorder) [8]

Health benefits of lithium

Below is a quick list of ten lesser-known health advantages of lithium. While this list is not exhaustive, it supplies insight into how this powerhouse nutrient can increase your total health.

Promotes regular brain health

While many people associate lithium with brain health, you might not comprehend the many ways it helps. The mineral can improve noodle in the prefrontal cortex area of the brain– the part connected with feeling, thought, and character– in otherwise healthy people, along with white matter.

Researchers suggested that lithium does this by stimulating the brain to generate new stem cells, which then develop into neurons.

Research has found that the neuroprotection residential or commercial properties of lithium can reinvent the field of brain research and neurodegenerative disease.

However, other studies discovered this apparent boost was perhaps an artifact of the MRI imaging used to determine it, and lithium-induced brain hydration might actually account for the higher noodle volume measured.

The jury’s out, but research does show lithium’s ability to safeguard the brain from typical wear and tear (neuroprotection) and to prevent typical age-related brain shrinking.

You can utilize lower amounts of lithium orotate to support restorative brain levels of lithium for longer time periods, and with fewer adverse effects. These findings might reinvent the field of brain research study and neurodegenerative disease.

Supports bone health

The effects of calcium and phosphorus, two minerals essential to bone development, may be improved through lithium supplements. Some research suggests lithium’s possible to support bone strength.

Lithium appears to decrease the threat of bone fractures. Lithium chloride salt also assisted bone fractures recover by activating the “Wnt signaling path”– a way the body communicates to fix broken tissues, consisting of bone. However, the scientists just observed this recovery result when a fracture occurs. Lithium chloride also helped damaged cartilage recover.

Improves focus & attention

One randomized, double-blind study found that lithium worked comparably to a popular mind medication for the most typical symptoms of attention deficit disorder and even secondary signs like mood imbalance.

The study looked specifically at how lithium affects irritation, aggressive outbursts, antisocial behavior, stress and anxiety, and depression in grownups. It also tested how the adults performed on tests of spoken learning and sustained attention.

Supports immune health

Recent research study found that lithium may have powerful immune-bolstering effects, simultaneously putting in immune-stimulating residential or commercial properties in addition to assisting the body withstand damaging organisms.

Lithium appears to stabilize levels of prostaglandin– tiny signalers in every cell of the body that modulate a variety of metabolic actions.

Excessive prostaglandin activity can depress your body immune system; however, lithium may contribute in avoiding its immune-suppressing results.

May assist you live longer

Interesting research study from Japan showed a strong connection in between lithium and how long you live.

The research study analyzed 18 water municipalities with over 1.2 million citizens. They discovered lower death rates from all causes in the population groups receiving greater levels of lithium in the supply of water.

Not only that, the scientists found when they gave Caenorhabditis elegans roundworms (a design organism frequently utilized in anti-aging studies) comparably low portions of lithium, it likewise extended their life expectancy.

Lithium may have antioxidant residential or commercial properties understood to offer anti-aging benefits that enhance longevity. Particularly, lithium decreased destructive complimentary radicals in the hippocampus part of the brain, though the research study recommended the mineral can’t entirely counter the effects of chronic stress.

Strengthens cardiovascular health

Lithium might increase heart and cardiovascular health in unexpected ways. One research study discovered that the electrocardiograms of people who took lithium had lower “T wave amplitude”– an indicator of cardiac arrest– with no decline in heart function. Nevertheless, this was at a relatively high therapeutic dose of lithium carbonate, which is only offered in prescription type.

Early research study also reveals that lithium boosts the body’s production of VEGF (Vascular Endothelial Growth Element), a protein that helps your body form new blood vessels.

VEGF belongs to the system that restores oxygen to tissues when they are not getting oxygen. The scientists suggest lithium might help stroke victims recover by increasing the speed at which capillary regrow in the brain, likewise called “neurovascular improvement.”.

Enhances cognitive function

Lithium motivates nerve cells to form synapses, which are the connections in between the nerve cells. Scientists cultured rat neurons from the hippocampus– the part of the brain that organizes ideas and memories– and discovered that when rat neurons were grown in culture (Petri dishes) with lithium, they formed significantly more synapses than without the lithium– over just four hours.

By encouraging neurons to form synapses and grow, lithium boosts your cognitive skills, memory, and even focus!

When brand-new nerve cells grow, it enhances your focus, memory and cognitive function (” thinking abilities”). The authors suggest this may represent the gray matter increase seen in some research studies. Studies have also shown an increase in neural stem cells, undifferentiated cells that will eventually become nerve cells.

Besides the hippocampus, researchers have seen development in the frontal cortex part of the brain, which influences cognitive abilities, supports state of mind, and improves focus, and memory. People taking lithium had as much as 15 percent greater gray matter compared to those not taking it; however, that was in patients taking prescription medication at higher doses.

Stabilizes mood

Lithium is known to normalize state of mind. Less popular is that lithium can stabilize state of mind in low micro-servings for healthy individuals. Beyond common mood swings, studies have actually discovered lithium even minimizes the danger of suicide– even at very low quantities, such as 70 to 170 mcg (micrograms) discovered in water materials.

One study in Texas discovered people living in areas with higher levels of lithium in the water had regularly lower rates of suicide, aggressive crimes, and drug arrests. Similar findings were found in a research study from Japan.

For less major moody blues, low-servings of lithium may also stabilize feelings and improve your response to short-lived anxiety or stress. One research study showed that people provided micro-servings of lithium over four weeks reported progressively enhanced state of mind in locations connected to happiness, friendliness, and energy.

Helps headaches

Promising research study shows that lithium orotate is a reliable treatment for headaches. One research study provided 64 clients lithium orotate and concluded that it works for periodic headaches.

Did you know that lithium is useful for various kinds of periodic headaches?

Another study showed that lithium can calm the seriousness of headaches.

Lithium is likewise known to help hypnic or “alarm clock headaches” which often impact the elderly, waking them from sleep at the same time each night. Those occasional, nightly headaches otherwise interfere with circadian rhythms and take away from restful sleep. The authors suggest that lithium might favorably affect serotonin in the body, which promotes sleep.

Could help with alcohol cravings

Many people are dissatisfied enough that they turn to unhealthy sources of comfort such as alcohol. For these individuals, lithium might minimize yearnings.

In one study, 42 patients in a rehabilitation center for alcohol addiction were provided everyday dosages of lithium orotate for 6 months. According to the study, “Ten of the patients had no relapse for over 3 and as much as 10 years, 13 clients stayed without relapse for 1 to 3 years, and the staying 12 had regressions between 6 to 12 months.”.

The scientists concluded that lithium orotate is useful in enhancing situations where alcohol is triggering concerns. Other research studies have actually confirmed that lithium may help promote sobriety.

Make no mistake, if you’re battling alcoholism or drug dependency, get assistance. However, for people getting support for giving up drinking, lithium might help them stay the course. [9]

Negative effects of lithium

Individuals who take lithium may experience a number of typical negative effects, consisting of:.

  • headaches
  • queasiness and vomiting
  • diarrhea
  • dizziness or sleepiness
  • hand tremblings
  • dry mouth
  • increased thirst
  • modifications in cravings
  • increased urination
  • loss of hair or thinning of hair
  • acne
  • psoriasis
  • hyperparathyroidism
  • hypothyroidism
  • an irregular heart beat [10]


The dosage of this medication will be different for different clients. Follow your physician’s orders or the directions on the label. The following info consists of just the typical doses of this medication. If your dose is different, do not alter it unless your medical professional informs you to do so.

The amount of medicine that you take depends upon the strength of the medication. Also, the variety of doses you take each day, the time enabled in between dosages, and the length of time you take the medicine depend upon the medical problem for which you are utilizing the medication.

For oral dose forms (capsules, service, and tablets):.

For intense mania:

Grownups and kids 7 years of age and older weighing more than 30 kilograms (kg)– 600 milligrams (mg) or 10 milliliters (mL) 2 to 3 times a day. Your medical professional might adjust your dosage as required.

Children 7 years of age and older weighing 20 kg to 30 kg– 600 mg to 1500 mg or 10 mL to 25 mL given in divided doses each day. Your doctor might change your dose as needed.

Children 7 years of age and older weighing less than 20 kg– Usage and dosage should be determined by your doctor.

Children more youthful than 7 years of age– Use is not recommended.

For long-term treatment of mania:

Adults and kids 7 years of age and older weighing more than 30 kgs (kg)– 300 mg to 600 mg or 5 mL to 10 mL 2 to 3 times a day. Your physician might change your dosage as needed.

Kids 7 years of age and older weighing 20 kg to 30 kg– 600 mg to 1200 mg or 10 mL to 20 mL given in divided dosages daily. Your medical professional might change your dose as needed.

Children 7 years of age and older weighing less than 20 kg– Usage and dose must be figured out by your doctor.

Kids younger than 7 years of age– Usage is not suggested.

For oral dosage type (extended-release tablets):.

For severe mania:

Grownups and kids 12 years of age– 900 milligrams (mg) 2 times a day, or 600 mg 3 times a day.

Kids younger than 12 years of age– Usage is not recommended.

For long-term treatment of mania:

Adults and children 12 years of age– 600 milligrams (mg) 2 times a day, or 3 times a day as much as 1200 mg per day.

Kids more youthful than 12 years of age– Usage is not suggested. [11]


  • Medications for anxiety (Antidepressant drugs) interaction rating: Major Do not take this combination.
  • Lithium increases a brain chemical called serotonin. Some medications for anxiety also increase the brain chemical serotonin. Taking lithium together with these medications for anxiety may increase serotonin excessive and cause major adverse effects consisting of heart issues, shivering, and anxiety. Do not take lithium if you are taking medications for anxiety.
  • Some of these medications for depression consist of fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Tofranil), and others.
  • Medications for depression (MAOIs) interaction ranking: Major Do not take this mix.
  • Lithium increases a chemical in the brain. This chemical is called serotonin. Some medications utilized for anxiety likewise increase serotonin. Taking lithium with these medications used for depression might cause there to be excessive serotonin. This could cause serious side effects consisting of heart issues, shivering, and stress and anxiety.
  • Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.
  • Dextromethorphan (Robitussin DM, and others) interaction score: Moderate Be cautious with this combination. Talk with your health service provider.
  • Lithium can impact a brain chemical called serotonin. Dextromethorphan (Robitussin DM, others) can also impact serotonin. Taking lithium together with dextromethorphan (Robitussin DM, others) might cause too much serotonin in the brain and major side effects consisting of heart issues, shivering, and anxiety might result. Do not take lithium if you are taking dextromethorphan (Robitussin DM, and others).
  • Medications for hypertension (ACE inhibitors) interaction ranking: Moderate Be cautious with this combination. Talk with your health provider.
  • Some medications for high blood pressure can increase lithium levels in the body. Taking lithium together with some medications for hypertension may trigger too much lithium to be in the body.
  • Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others.
  • Medications for hypertension (Calcium channel blockers) interaction score: Moderate Be cautious with this mix. Talk with your health supplier.
  • Lithium is frequently used to assist fix chemical imbalances in the brain. Some medications for high blood pressure may increase the negative effects of lithium, and reduce the amount of lithium in the body.
  • Some medications for hypertension include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others.
  • Medications utilized to prevent seizures (Anticonvulsants) interaction rating: Moderate Beware with this mix. Talk with your health supplier.
  • Medications used to prevent seizures affect chemicals in the brain. Lithium is frequently utilized to assist fix chemical imbalances in the brain. Taking lithium together with some medications used for seizures may increase the side effects of lithium.
  • Some medications utilized to prevent seizures include phenobarbital, primidone (Mysoline), valproic acid (Depakene), gabapentin (Neurontin), carbamazepine (Tegretol), phenytoin (Dilantin), and others.
  • Meperidine (Demerol) interaction rating: Moderate Beware with this mix. Talk with your health provider.
  • Lithium increases a chemical in the brain called serotonin. Meperidine (Demerol) can also increase serotonin in the brain. Taking lithium along with meperidine (Demerol) might cause excessive serotonin in the brain and major side effects including heart issues, shivering, and stress and anxiety.
  • Methyldopa (Aldomet) interaction rating: Moderate Be cautious with this combination. Talk with your health supplier.
  • Taking methyldopa might increase the impacts and adverse effects of lithium. Do not take lithium if you are taking methyldopa unless prescribed by your health care specialist.
  • Methylxanthines interaction ranking: Moderate Be cautious with this mix. Talk with your health company.
  • Taking methylxanthines can increase how rapidly the body eliminates lithium. This could reduce how well lithium works.
  • Methylxanthines include aminophylline, caffeine, and theophylline.
  • Muscle relaxants interaction score: Moderate Beware with this combination. Talk with your health supplier.
  • Lithium might increase the length of time muscle relaxants work. Taking lithium in addition to muscle relaxants may increase the effects and negative effects of muscle relaxants.
  • A few of these muscle relaxants include carisoprodol (Soma), pipecuronium (Arduan), orphenadrine (Banflex, Disipal), cyclobenzaprine, gallamine (Flaxedil), atracurium (Tracrium), pancuronium (Pavulon), succinylcholine (Anectine), and others.
  • NSAIDs (Nonsteroidal anti-inflammatory drugs) interaction score: Moderate Be cautious with this combination. Talk with your health supplier.
  • NSAIDs are anti-inflammatory medications utilized for decreasing pain and swelling. NSAIDs might increase lithium levels in the body. Taking lithium in addition to NSAIDs may increase the risk of lithium negative effects. Prevent taking lithium supplements and NSAIDs at the same time.
  • Some NSAIDs consist of ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene), aspirin, and others.
  • Phenothiazines interaction ranking: Moderate Beware with this combination. Talk with your health service provider.
  • Taking phenothiazines in addition to lithium might reduce the effectiveness of lithium. Lithium may likewise reduce the effectiveness of phenothiazines.
  • Some phenothiazines include chlorpromazine (Thorazine), fluphenazine (Prolixin), trifluoperazine (Stelazine), thioridazine (Mellaril), and others.
  • Tramadol (Ultram) interaction score: Moderate Be cautious with this combination. Talk with your health supplier.
  • Tramadol (Ultram) can affect a chemical in the brain called serotonin. Lithium can also impact serotonin. Taking lithium together with tramadol (Ultram) may cause excessive serotonin in the brain triggering confusion, shivering, stiff muscles, and opposite results.
  • Water pills (Loop diuretics) interaction ranking: Moderate Beware with this combination. Talk with your health supplier.
  • Some “water pills” can increase how much salt the body gets rid of in the urine. Decreasing salt in the body can increase lithium levels in the body and increase the results and side effects of lithium.
  • Water tablets (Thiazide diuretics) interaction ranking: Moderate Be cautious with this combination. Talk with your health service provider.
  • Taking lithium with some “water pills” can increase the amount of lithium in the body. This can cause severe side effects. Talk with your healthcare provider if you are taking lithium before taking “water pills.”
  • Some kinds of “water tablets” include chlorothiazide (Diuril), hydrochlorothiazide (HydroDiuril, Esidrix), indapamide (Lozol), metolazone (Zaroxolyn), and chlorthalidone (Hygroton).
  • Pentazocine (Talwin) interaction score: Minor Be cautious with this combination. Talk with your health service provider.
  • Lithium increases a brain chemical called serotonin. Pentazocine (Talwin) likewise increases serotonin. Taking lithium along with pentazocine (Talwin) may cause too much serotonin in the body. Taking lithium in addition to pentazocine (Talwin) may cause major negative effects consisting of heart problems, shivering, and anxiety. Do not take lithium supplements if you are taking pentazocine (Talwin). [12]


It is really important that your medical professional inspect your or your kid’s progress at routine visits to make certain that this medication is working correctly. Blood and urine tests might be required to look for unwanted adverse effects.

Using this medicine while you are pregnant can harm your coming child. Utilize an effective kind of contraception to keep from getting pregnant. If you believe you have become pregnant while utilizing the medication, inform your physician right now.

Call your doctor right away if you have diarrhea, vomiting, drowsiness, muscle weak point, tremors, unsteadiness, or other issues with muscle control or coordination. These might be signs of lithium toxicity.

Make sure your physician understands if you have a heart condition called Brugada syndrome. Brugada syndrome can be lethal and requires immediate medical attention. Call your medical professional or the emergency situation department right away if you have a quick, pounding, or uneven heart beat, inexplicable fainting, lightheadedness, or troubled breathing after utilizing this medication.

This medicine might trigger pseudotumor cerebri (increased pressure in the brain). Call your medical professional immediately if you have actually blurred or double vision, dizziness, eye discomfort, extreme headache, or nausea and vomiting. [13]


Lithium upkeep was associated with significant decrease of lethal self-destructive acts, the number of which dramatically increased after discontinuing lithium. Suicidal habits was highly related to previous suicide efforts, more time depressed, and younger age or current start. [14]


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