Gotu Kola

Centella asiatica, commonly called gotu kola, kodavan, indian pennywort and asiatic pennywort, is an herbaceous, seasonal plant in the flowering plant family apiaceae. It is belonging to wetlands in the caucasus, tropical & subtropical vintage to brand-new zealand and the west pacific. It is used as a cooking vegetable and as a medicinal herb. (1 )

Summary

Gotu kola (centella asiatica) is an herb in the parsley family. It has a long history of use in the conventional chinese and ayurvedic medicine systems.

Gotu kola includes certain chemicals that appear to reduce swelling and blood pressure. It also seems to increase collagen production, which might be helpful for wound healing.

Individuals use gotu kola for burns and bad circulation that can cause varicose veins. It is likewise utilized for scars, stretch marks, and many other conditions, however there is no good scientific proof to support the majority of these uses. (2 ).

History

Gotu kola (centella asiatica) has actually been used to treat many conditions for countless years in india, china, and indonesia. It was used to heal wounds, enhance mental clearness, and deal with skin problem such as leprosy and psoriasis.

Some individuals utilize it to deal with breathing infections, such as colds, and in the past it was used for that in china. It has actually been called “the water fountain of life” because legend has it that an ancient chinese herbalist lived for more than 200 years as a result of taking gotu kola.

Historically, gotu kola has actually likewise been used to deal with syphilis, hepatitis, stomach ulcers, mental fatigue, epilepsy, diarrhea, fever, and asthma. Today, in the u.s. And europe gotu kola is most often used to deal with varicose veins and chronic venous deficiency, a condition where blood pools in the legs. It is likewise used in ointments to deal with psoriasis and assistance heal small injuries.

Gotu kola is not the like kola nut (soda pop nitida). Unlike kola nut, gotu kola does not have caffeine, and is not a stimulant. (3 ).

Description

Gotu kola (centella asiatica) is a member of the apiaceae carrot household. It is also called pennywort, marsh cent, water pennywort, and sheep rot. The name sheep rot originates from the incorrect belief in europe that gotu kola caused foot rot in sheep. Gotu kola is frequently incorrect for the kola nut plant (soda nitida). Nevertheless, the two are not related and gotu kola, unlike the kola nut, consists of no caffeine. Gotu kola is noted in india as a really effective spiritual herb, and ayurvedic medication refers to it as brahmi since it helps obtain knowledge of the soul.

Gotu kola, a seasonal, grows in india, sri lanka, madagascar, south africa, china, indonesia, australia, and north america. It can grow like a weed, but its description depends on its area. For example, in shallow water, the leaves float; but in dry areas, the plant develops lots of roots and thin, small leaves. The fan-shaped leaves may be smooth or lobed. Red flowers become fruit with a size of about 0.2 in (5 mm).

Gotu kola’s primary active parts are triterpenoids, although the gotu kola discovered in india, sri lanka, and madagascar does not have the same residential or commercial properties. Gotu kola’s triterpenes can have a concentration from 1.1-8%, with the majority of concentrations in the center variety.

Gotu kola from madagascar is used for the majority of standardized extracts, and its four primary triterpene homes are:.

• Asiatic acid (29-30%)
• Madecassic acid (29-30%)
• Asiaticoside (40%)
• Madecassoside (1-2%)

Gotu kola likewise consists of the following.

• Unstable oil of a terpene acetate (36% of all the unstable oil)
• Camphor
• Cineole
• Glycerides of some fats
• Plant sterols (campesterol, stigmasterol, sitosterol)
• Polyacetylene compounds
• Flavonoids (kampferol, quercetin)
• Myo-inositol (glycoside from the flavonoids)
• Sugars
• Vellarin
• Amino acids
• Resins (4 )

Clinical research studies

The majority of the clinical research studies on asian ca have been understood with alcoholic or aqueous extracts. The teca extracts (titrated extracts of asian ca and ttfca (triterpenic overall portion of asian ca) are combinations of asiatic acid (30%), madecasic acids (30%) and asiaticoside (40%). The ttf extract (triterpenic total fraction) includes asian ca and madecasic acids (60%) in a relation not clearly defined yet, in mix with asiatichoside (40%). Both in vivo medical studies and human monolayer cell culture experiments have actually concluded that asiatic acid affects collagen synthesis. The selective action of the local application of triterpenoid fraction of cae for injury recovery and highlighted the function of asiaticoside in the increased levels of antioxidants (enzymatic and nonenzymatic), which were also indicated for the sped up wound healing. It is now known that angiogenesis plays an essential function in injury healing because the newly formed capillary assist the hypoxic injuries to attain normoxic conditions. Asiaticoside prompted angiogenesis in both in vivo and in vitro designs. In cases of vascular injury, thrombosis, acute myocardial infarction, and other peripheral vascular diseases, a higher variety of distributing endothelial cells was discovered. For instance, in one research study, clients with post phlebetic syndrome (pps) revealed a greater number of distributing endothelial cells compared to the typical subjects. Throughout a three-week treatment with ca triterpenic portion (catf), pps patients who received 90 mg catf daily in 3 divided does revealed a statistical considerable reduction in distributing endothelial cells, consequently suggesting the efficiency of ca in safeguarding the stability of vascular intima. The lower variety of distributing endothelial cells was credited to the protective result of catf on vascular intima integrity. The extract of ca was checked on 94 patients struggling with venous insufficiency of the lower limbs. The patients were divided into 3 groups, each treated with teca (120 mg/day, 60 mg/day or placebo) for two months. An analytical significant distinction in favour of teca groups was observed in the criteria checked for lower limbs and edema; likewise the total examination was revealed positive for the teca treated groups compared to the placebo. Catf proved to be reliable on microcirculation and capillary permeability. Fifty-two patients with venous hypertension (pressure greater than 42 mmhg) were divided into three groups, each treated with 60 mg/day, 30 mg/day, or placebo. The extra 10 control topics were treated with 60 mg/day. After 4 weeks of treatment substantial improvements were observed in a concentration-dependent way in the parameters checked, such as filtration rate, ankle edema, and ankle circumference. No substantial modifications were observed in placebo and control topics treated with catf. In another double-blind clinical trial including 87 clients with chronic venous hypertensive microangiopathy, two dosage forms of catf (30 mg/day and 60 mg/day) were gotten 60 days and no undesirable results were observed. The results also validated the effectiveness of catf in a dose-dependent manner. The impacts of the catf on enzymes involved in mucopolysaccharide metabolism supported the hypothesis that the extract acts on fundamental metabolism in the connective tissues of the vascular wall. The levels of basal serum uronic acid and enzymes associated with mucopolysaccharide metabolism (beta-glucuronidase, beta-n-acetylglucosaminidase, and arylsulfatase) rose in clients with varicose veins, suggesting an increased muco-polysaccharide turnover. After treatment (60 mg/day for 3 months) the above enzyme levels fell progressively.

A double-blind, placebo-controlled study was conducted to inspect the results of an oral standardized ca item in 2 dosages (30 mg bid and 60 mg quote) in 87 clients with persistent venous hypertensive microangiopathy. Microcirculatory specifications were revealed to be enhanced as compared to placebo in dosage reliant way, with the higher dose improving symptoms more considerably. Another research study reported the useful impacts of an oral standardized ca product (60 mg 3 times a day over a 2month period) in vascular permeability and microcirculation as assessed by laser doppler flowmetry. The results showed a combined improvement of the microcirculation and capillary permeability in all patients (10 typical topics, 22 clients with moderate, shallow venous high blood pressure, and 12 patients with postphlebitic limbs and extreme venous high blood pressure). Another research study in patients with extreme venous high blood pressure due to deep venous illness reported that a standardized ca extract was acutely effective in minimizing capillary purification and edema in individuals with venous hypertensive microangiopath. Ca preparations were found helpful in decreasing the stretch marks (striae gravidarum) that lots of women establish during pregnancy. A placebo-controlled research study of 100 pregnant ladies compared application of a cream including a cae, vitamin e (alpha tocopherol), and collagen-elastin hydrolysates to placebo. Application of the intensified cream was associated with less ladies establishing stretch marks than in placebo. Application of topical ca preparations were shown to be helpful in decreasing the scarring seen during wound healing, seeming associated with the stimulation of maturation of the scar by the production of type i collagen and the resulting reduction in the inflammatory response and myofibroblast production. In a randomized, double-blind, vehicle-controlled, half-side contrast research study, undertaken to figure out if it could likewise improve mild-to-moderate atopic dermatitis in grownups, eighty-eight individuals were randomly applied the treatment lotion and the placebo control to either the left or best side of the body for 4 weeks (2 applications per day) after which erythema, edema, oozing, and excoriation were assessed. No significant enhancements were discovered in the treatment group as compared to the control group; however, additional analysis of patients living in chillier environments showed a considerable improvement in the treated areas. Due to the fact that the ointment consisted of the mix of herbs, it was suggested that further studies using each specific herb and studies utilizing a parallel group style were required to be performed.

In one current randomized, placebo-controlled, double-blind study, 28 participants (< <61 years of age) got either ca extracts (250, 500, or 750 mg daily) or placebo in order to identify the effect of ca on cognitive function and state of mind. In the study, after 2 months, cognitive function (as assessed by event-related possible and the electronic evaluation battery test) and state of mind (using bond-lader visual analogue) was figured out. The best enhancements in mood and cognitive function were identified in those receiving the 750 mg dose of ca extract. A double-blind, placebo-controlled study investigated the anxiolytic activity of ca in human topics. The authors concluded that the findings suggested ca's anxiolytic activity in humans. Extremely just recently, a research study was conducted in sixty senior subjects in age 65 and above, utilizing diagnostic tools like mini mindset assessment scoring (mmse scoring), in which activities of day-to-day living and yesavage geriatric anxiety scale were examined. The mean mmse scoring revealed considerable improvement after administration of ca for 6 months in senior with moderate cognitive problems (mci) at dose of 500 mg twice a day (1000 mg everyday). A beneficial improvement is observed in depression and other age related conditions like high blood pressure, peripheral neuritis, sleeping disorders, anorexia nervosa, constipation a sign of several helpful scientific effects of ca especially in the age-related cognitive decrease in elderly. (5 ).

Benefits of gotu kola

It may help boost cognitive function

A small 2016 study compared the effects of gotu kola extract and folic acid in increasing cognitive function after a stroke. This little research study assessed the influence on 3 groups of individuals– one taking 1,000 milligrams (mg) of gotu kola daily, one taking 750 mg of gotu kola each day, and one taking 3 mg of folic acid per day.

Although gotu kola and folic acid were equally useful in enhancing general cognition, gotu kola was more effective in improving memory domain.

A separate study looked at the cognitive enhancing results of gotu kola water extract on mice. Although both young and old mice showed improvements in learning and memory using the morris water maze, the result was greater in the older mice.

How to utilize: take 750 to 1,000 mg of gotu kola daily for up to 14 days at a time.

It might assist treat alzheimer’s disease

Gotu kola has the ability to improve memory and nerve function, which offers it potential in dealing with alzheimer’s disease. In fact, one 2012 research study on mice found that gotu kola extract had a positive effect on behavioral problems in mice with alzheimer’s disease.

The extract was likewise revealed, in lab and animal studies, to have a modest effect on securing brain cells from toxicity. This could likewise safeguard the cells from forming the plaque connected with alzheimer’s.

Still, more research study is required to determine precisely how gotu kola could be utilized to treat alzheimer’s. If you’re interested in including this to your treatment plan, talk to your physician prior to usage.

How to use: take 30 to 60 drops of liquid gotu kola draw out 3 times per day. Does might vary between producers, so constantly carefully follow the instructions on the bottle.

It might help in reducing stress and anxiety and stress

Researchers in an animal study from 2016 found that gotu kola had an anti-anxiety result on male mice that were sleep denied for 72 hours. Sleep deprivation can cause stress and anxiety, oxidative damage, and neuro inflammation.

Mice that were provided gotu kola for 5 successive days prior to going through sleep deprivation experienced substantially less anxiety-like habits. They likewise experienced improved locomotor activity and less oxidative damage.

A 2013 review of anti-anxiety organic medications likewise concluded that gotu kola has an intense anti-anxiety effect. However, more research is required to verify these findings.

How to use: take 500 mg of gotu kola extract two times a day for as much as 2 week at a time. You can take up to 2,000 mg daily in cases of severe stress and anxiety.

It might function as an antidepressant

Gotu kola’s positive impact on brain function might also make it an effective antidepressant.

A review from 2016 supports these findings, in part due to a research study on 33 people with generalized anxiety condition. The participants were asked to take gotu kola in place of their antidepressant medication for 60 days. They self-reported reduced stress, anxiety, and anxiety.

Another research study discussed in the evaluation assessed the result of gotu kola on rats caused with chronic anxiety. The herbal solution had a positive impact on particular elements of behavioral depression, including body weight, body temperature level, and heart rate.

How to use: take 500 mg of gotu kola twice a day for approximately 2 week at a time. You can use up to 2,000 mg each day throughout times of magnified depression.

It may enhance blood circulation and lower swelling

Research from 2001 discovered that gotu kola can minimize problems with fluid retention, ankle swelling, and circulation connected to taking flights that last longer than 3 hours.

Individuals who experienced mild-to-moderate shallow venous illness with varicose veins were asked to take gotu kola for 2 days prior to their flight, the day of their flight, and the day after their flight.

Researchers found that participants who took the supplement experienced considerably less fluid retention and ankle swelling than those who didn’t.

Older research has actually likewise revealed that gotu kola can be helpful in dealing with varicose veins. This might be because gotu kola has a positive metabolic effect on the connective tissue of the vascular wall.

How to use: take 60 to 100 mg of gotu kola extract 3 times each day for a week, before and after any flights. You can also massage the afflicted area with a topical cream consisting of 1 percent gotu kola extract.

How to do a skin patch test: it is essential to do a patch test before utilizing any topical medication. To do this, rub a dime-sized amount on to the inside of your forearm. If you don’t experience any irritation or swelling within 24 hr, it needs to be safe to use in other places.

It may help ease insomnia

Provided its perceived capability to treat stress and anxiety, stress, and depression, gotu kola may also be utilized to treat the sleeping disorders that sometimes accompanies these conditions. Some consider this herbal treatment to be a safe option to prescription medications used to deal with insomnia and other sleep disorders.

Although older research study does recommend that gotu kola can help deal with sleep disorders, additional research studies are required to verify these findings.

How to utilize: take 300 to 680 mg of gotu kola draw out 3 times daily for as much as 14 days at a time.

It might help in reducing look of stretch marks

According to a 2013 review, gotu kola can decrease the appearance of stretch marks. It’s thought that the terpenoids found in gotu kola increase collagen production in the body. This may assist prevent brand-new stretch marks from forming, as well as help recover any existing marks.

How to use: use a topical cream including 1 percent gotu kola extract to the affected location a number of times per day.

How to do a skin patch test: it is necessary to do a patch test prior to using any topical medication. To do this, rub a dime-sized amount on to the within your forearm. If you don’t experience any inflammation or inflammation within 24 hr, it must be safe to utilize somewhere else.

It may promote wound recovery and minimize scarring

Researchers in a 2015 research study on rats discovered that wound dressing consisting of gotu kola had healing impacts on several kinds of injuries. This consists of tidy cuts by sharp things, irregular tears caused by blunt-force injury, and infected tissue.

Although appealing, further research study is needed to confirm these findings.

How to use: use an ointment including 1 percent gotu kola extract to the afflicted area a number of times daily. If your wound is deep or otherwise serious, see your doctor prior to usage.

How to do a skin patch test: it’s important to do a patch test prior to utilizing any topical medication. To do this, rub a dime-sized amount on to the inside of your lower arm. If you don’t experience any inflammation or inflammation within 24 hours, it needs to be safe to utilize in other places.

It may help eliminate joint pain

The anti-inflammatory homes of gotu kola may be useful in dealing with arthritis.

In fact, one 2014 study on collagen-induced arthritis in rats discovered that oral administration of gotu kola decreased joint inflammation, cartilage disintegration, and bone erosion. Its antioxidant effect likewise had a favorable impact on the immune system.

How to use: take 300 to 680 mg of gotu kola extract 3 times per day for approximately 2 week at a time.

It may have a detox result

Newer research is having a look at gotu kola’s result on liver and kidney toxicity.

According to one 2017 animal study, gotu kola can be utilized to suppress the toxic side effects of the antibiotic isoniazid. Isoniazid is utilized to deal with and prevent tuberculosis.

Rats were provided 100 mg of gotu kola for 1 month before they were offered the antibiotic. These rats experienced less toxicity overall. Rats that did experience toxicity in the liver and kidneys resumed to near-normal levels after being given gotu kola.

More research study is required to broaden upon these findings.

How to utilize: take 30 to 60 drops of liquid gotu kola extract 3 times each day for as much as 2 week at a time. Dosages might vary between manufacturers, so constantly carefully follow the instructions on the bottle. (6 ).

Nutritional truths

In southeast asia, gotu kola is used as much for food as for medicinal functions. A member of the parsley household, gotu kola is an outstanding source of important vitamins and minerals required to keep ideal health.

According to an evaluation in the worldwide food research study journal, 100 grams of fresh gotu kola provides the following nutrients and meets the following advised dietary intake (rdi) needs:.

• Calcium: 171 milligrams (17% of the rdi)
• Iron: 5.6 milligrams (31% of the rdi)
• Potassium: 391 milligrams (11% of the rdi)
• Vitamin a: 442 micrograms (49% of the rdi)
• Vitamin c: 48.5 milligrams (81% of the rdi)
• Vitamin b2: 0.19 milligrams (9% of the rdi)

gotu kola is also a good source of dietary fiber, offering 8 percent of the rdi for ladies and 5 percent of the rdi for guys. (7 ).

Advantages of gotu kola in your skin care products

Gotu kola is abundant with anti-oxidants. It enhances the skin’s ability to fend off environmental stressors that can ruin your skin, and eliminates pollutants that can bring about indications of early aging like dark areas, wrinkles, and dull skin.

It has cleaning residential or commercial properties. It rids your face of yuck and filth like dirt, germs, and pore-clogging oil (good thing it remains in our mild so tidy! Cleanser).

It can brighten, tighten up, and smooth skin. Because of this it can drastically minimize the appearance of scarring, great lines, and wrinkles. It’s also wonderful for your eye area, which is why we’ve included it in our eyes infant eye cream, as it can minimize the look of dark circles and puffiness. In general, it will revitalize and renew your skin assisting you feel fresh dealt with and fabulous!

It’s a super soother. Full of soothing residential or commercial properties, gotu kola minimizes temporary redness and alleviates pain associated with skin level of sensitivity. This makes it a terrific active ingredient to search for if you have delicate skin.

It’s a majorly efficient hydration station. Gotu kola aids the skin in retaining wetness and can help attain that youthful, fresh radiance that just comes from appropriate quantities of h2o. This is what makes it an essential ingredient in our crème de la cream moisturizer. Hydrated skin is the ultimate method to keep typical signs of aging at bay. (8 ).

Side effects of gotu kola

Some reported negative effects of gotu kola consist of:

• Drowsiness
• Gastrointestinal discomfort
• Skin problems
• Lightheadedness
• Queasiness
• Headaches

Although there is restricted appropriate information, it is possible that gotu kola can interact with prescription or over the counter medications.

It is important to consult a doctor prior to using gotu kola. Make certain that the doctor learns about all ongoing medications and treatments. (9 )

Gotu kola tea recipe and benefit

Gotu kola (indian pennywort or mandukparni, centella asiatica, hydrcotyle asiatica) is a medical herb, which is utilized in ayurveda from centuries to treat brain function related problems such as bad memory, low mental abilities, anxiety, speech problems and sleeplessness. Gotu kola tea, which is prepared from the plant of centella asiatica is easy to make and provides lots of health advantages. This tea is particularly beneficial in inducing sound sleep.

For preparing this tea, one teaspoon of finely shredded dried/fresh gotu kola leaves are taken in a cup of warm water. The cup is covered with cover and the leaves are soaked for 10-15 minutes. After fifteen min tea is ready to consume. For stronger taste, you can steep leaves for more time. You can prepare and consume this tea 3-4 times a day.

Gotu kola tea provides many health advantages. It is brain tonic, which minimizes tension, stress and anxiety, tumors, and remedies insomnia/sleeplessness and anxiety. It also improves mental abilities, memory, intellect and gets rid of mental tiredness. Gotu kola tea removes toxins from the liver and blood, improves energy levels and reinforces the kidneys. According to ayurveda, it balances intensified vata and pitta in the body. (10 ).

Dosing

The advised daily dosage of titrated extracts of c. Asiatica standardized for asiaticoside, asiatic acid, and madecassic acid is 60 to 120 mg. (11 ).

Interaction

Taking gotu kola with any medications that make you drowsy can aggravate this result. Ask your healthcare provider prior to taking gotu kola with medicine for stress and anxiety, depression, or seizures.

Gotu kola can damage your liver. This effect is increased when you likewise utilize other medications hazardous to the liver. Do not take gotu kola without medical guidance if you are using any of the following medications:.

• Acetaminophen (tylenol);
• Leflunomide, teriflunomide;
• Methotrexate;
• An antibiotic, antifungal medicine, sulfa drug, or tuberculosis medication;
• Birth control pills or hormonal agent replacement therapy;
• Heart or blood pressure medication;
• Cholesterol-lowering medications– crestor, lipitor, pravachol, simcor, vytorin, zocor, and others;
• Gout or arthritis medications (consisting of gold injections);
• Hiv/aids medications;
• Medicines to treat mental illness;
• An nsaid (non-steroidal anti-inflammatory drug)- ibuprofen (advil, motrin), naproxen (aleve), celecoxib (celebrex), diclofenac, indomethacin, meloxicam, others;
• Seizure medication– carbamazepine, phenytoin, and others; or
• Steroids (prednisone and others).

This list is not total. Other drugs might interact with gotu kola, consisting of prescription and over the counter medicines, vitamins, and herbal products. Not all possible interactions are noted in this product guide. (12 ).

Warnings

This medication includes gotu kola. Do not use brahmabuti, centella asiatica, hydrocotyle, indian pennywort, indian water navelwort, madescassol, marsh cent, talepetrako, thick-leaved pennywort, or white rot if you are allergic to gotu kola or any components contained in this drug.

Keep out of reach of kids. In case of overdose, get medical assistance or call a toxin control center immediately. (13 ).

Conclusions

Asiatica is an herb utilized in traditional chinese medicine. Its primary reliable elements are asiaticoside, asiatic acid, madecassoside, and madecassic acid. As pointed out previously, c. Asiatica and its triterpenoids have a vast array of medical values. In vivo and in vitro research studies showed that c. Asiatica and its triterpenoids had healing and easing results on multi-system illness. The c. Asiatica extract efficiently relieves sleep deprivation, advertisement, type 2 diabetes mellitus (t2dm), hyperlipidemia, gestational diabetes, baldness, atopic dermatitis, wound, drug-induced liver toxicity, liver injury, gastric mucosal injury, stomach ulcers, breast cancer, leukemia, oral submucous fibrosis, migraine, etc. Asiatic acid effectively relieves cognitive impairment, alzheimer’s disease, parkinson’s disease, weight problems, renovascular hypertension, transverse aortic constriction, myocardial ischemia/reperfusion (mi/r) injury, atherosclerosis, liver fibrosis, intense pancreatitis, colon carcinogenesis, hepatocellular cancer, pulmonary fibrosis, lung cancer, pelvic inflammatory, ovarian cancer, endometriosis, sepsis, periodontitis, etc. The preclinical studies on asiaticoside found that it has restorative capacity for the following diseases: hemiparkinsonism, alzheimer’s illness, cerebral ischemia, skin wound, lung hypertension, atherogenesis, ali, osteolytic bone illness, and so forth. Medicinal research studies found that madecassoside had possible therapeutic impact against osteoporosis, acne, vitiligo, ra, etc. Madecassic acid had a favorable therapeutic impact on ischemic retinopathies. The preclinical research study on centella asiatica primarily focused on the extract of c. Asiatica and asiatic acid. For illness, neurological and skin diseases are primarily examined. However, the influence on other diseases also requires further thorough expedition.

The incident of inflammatory response, oxidative tension, apoptosis, and mitochondrial dysfunction is closely related to different diseases. C. Asiatica and its triterpenoids can be used in many medical scenarios since they have anti-inflammatory and anti-apoptotic effects, relieve oxidant stress, and improve mitochondrial function. Hence further, c. Asiatica may likewise be applied to diseases not pointed out in this study by means of the exact same pathological mechanism, and this hypothesis needs extensive examination for confirmation. (14 ).

Referrals

1. Https://en.wikipedia.org/wiki/centella_asiatica
2. Https://www.webmd.com/vitamins/ai/ingredientmono-753/gotu-kola
3. Https://www.mountsinai.org/health-library/herb/gotu-kola
4. Https://www.encyclopedia.com/medicine/encyclopedias-almanacs-transcripts-and-maps/gotu-kola
5. Https://www.ncbi.nlm.nih.gov/pmc/articles/pmc3116297/
6. Https://www.healthline.com/health/gotu-kola-benefits#_noheaderprefixedcontent
7. Https://www.verywellhealth.com/the-benefits-of-gotu-kola-89566
8. Https://fleurandbee.com/blogs/news/gotu-kola-for-skin
9. Https://www.medicalnewstoday.com/articles/gotu-kola-benefits#side-effects
10. Https://www.bimbima.com/recipes/gotu-kola-tea-recipe-and-benefits/2292/
11. Https://www.drugs.com/npp/gotu-kola.html
12. Https://www.emedicinehealth.com/drug-gotu_kola/article_em.htm#drugs
13. Https://www.rxlist.com/consumer_gotu_kola/drugs-condition.htm
14. Https://www.frontiersin.org/articles/10.3389/fphar.2020.568032/full#h4